Amylose Derivatives as Versatile Chiral Selectors for Enantiomeric Separation in High-Performance Liquid Chromatography and Capillary Electrophoresis

Copyright: © 2014 Maher HM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Chiral molecules are constituents of a large proportion of therapeutic agents. Chiral compounds exist in two enantiomeric forms, which have identical molecular formula but they differ only in their interaction with the plane polarized light. The human body recognizes chirality and interacts differently with each enantiomer. Thus there can be marked differences between enantiomers in their pharmacological profile. Enantiomeric separations represent a critical subject in pharmaceutical analysis, since enantiomers of drug compounds may possess quite different pharmacological and toxicological properties. This is extremely important in order to obtain higher drug efficiency and to alleviate undesirable side effects. For this reason, establishment of rapid, selective and effective analytical methods has aroused a considerable need to verify the enantiomeric purity of chiral drugs [1].